RESUMEN
Abstract Purpose: To evaluate the technical feasibility and homogeneity of drug distribution of pressurized intraperitoneal aerosol chemotherapy (PIPAC) based on a novel process of intraperitoneal drug application (multidirectional aerosolization). Methods: This was an in vivo experimental study in pigs. A single-port device was manufactured at the smallest diameter possible for multidirectional aerosolization of the chemotherapeutic drug under positive intraperitoneal pressure. Four domestic pigs were used in the study, one control animal that received multidirectional microjets of 9 mL/sec for 30 min and three animals that received multidirectional aerosolization (pig 02: 9 mL/sec for 30 min; pigs 03 and 04: 3 mL/sec for 15 min). Aerosolized silver nitrate solution was applied for anatomopathological evaluation of intraperitoneal drug distribution. Results: Injection time was able to maintain the pneumoperitoneum pressure below 20 mmHg. The rate of moderate silver nitrate staining was 45.4% for pig 01, 36.3% for pig 02, 36.3% for pig 03, and 72.7% for pig 04. Conclusions: Intra-abdominal drug distribution had a broad pattern, especially in animals exposed to the drug for 30 min. Our sample of only four animals was not large enough to demonstrate an association between aerosolization and a higher silver nitrate concentration in the stained abdominal regions.
Asunto(s)
Animales , Neoplasias Peritoneales/tratamiento farmacológico , Sistemas de Liberación de Medicamentos/métodos , Aerosoles/administración & dosificación , Neoplasias Peritoneales/patología , Neoplasias Peritoneales/secundario , Peritoneo/efectos de los fármacos , Presión , Factores de Tiempo , Insuflación , Estudios de Factibilidad , Sistemas de Liberación de Medicamentos/instrumentación , Aerosoles/farmacocinética , Cavidad Abdominal , Sus scrofa , Modelos Animales de Enfermedad , Inyecciones IntraperitonealesRESUMEN
PURPOSE: To evaluate the technical feasibility and homogeneity of drug distribution of pressurized intraperitoneal aerosol chemotherapy (PIPAC) based on a novel process of intraperitoneal drug application (multidirectional aerosolization). METHODS: This was an in vivo experimental study in pigs. A single-port device was manufactured at the smallest diameter possible for multidirectional aerosolization of the chemotherapeutic drug under positive intraperitoneal pressure. Four domestic pigs were used in the study, one control animal that received multidirectional microjets of 9 mL/sec for 30 min and three animals that received multidirectional aerosolization (pig 02: 9 mL/sec for 30 min; pigs 03 and 04: 3 mL/sec for 15 min). Aerosolized silver nitrate solution was applied for anatomopathological evaluation of intraperitoneal drug distribution. RESULTS: Injection time was able to maintain the pneumoperitoneum pressure below 20 mmHg. The rate of moderate silver nitrate staining was 45.4% for pig 01, 36.3% for pig 02, 36.3% for pig 03, and 72.7% for pig 04. CONCLUSIONS: Intra-abdominal drug distribution had a broad pattern, especially in animals exposed to the drug for 30 min. Our sample of only four animals was not large enough to demonstrate an association between aerosolization and a higher silver nitrate concentration in the stained abdominal regions.
Asunto(s)
Aerosoles/administración & dosificación , Sistemas de Liberación de Medicamentos/métodos , Neoplasias Peritoneales/tratamiento farmacológico , Cavidad Abdominal , Aerosoles/farmacocinética , Animales , Modelos Animales de Enfermedad , Sistemas de Liberación de Medicamentos/instrumentación , Estudios de Factibilidad , Inyecciones Intraperitoneales , Insuflación , Neoplasias Peritoneales/patología , Neoplasias Peritoneales/secundario , Peritoneo/efectos de los fármacos , Presión , Sus scrofa , Factores de TiempoRESUMEN
Com o objetivo de verificar a prevalência de fumantes entre estudantes universitários e a diferença entre os sexos, foi realizado um estudo transversal entre 450 alunos de todas as unidades acadêmicas da PUCRS...
